# Prazosin MIGHT help



## Quarter Pounder (Jun 17, 2011)

So, I was doing some research and I ran into *this* thread in SomethingAwful (the thread is a bit old, so I could only find the Google cached version of it) where the OP says that he had derealization and that his psychiatrist ended up prescribing him a blood pressure medication called _prazosin_ which had "amazing effectiveness" among veterans with PTSD, and that after a single day of use he woke up and his DR had vanished.
Indeed, I looked it up and it did have proven to work, not only among PTSD sufferers, but among people with all sort of trauma-based issues. But what caught my attention the most is that this drug has a strong relationship with norepinephrine, which is a neurotransmitter that appears to be in a lower amount in people with DPD than in "normal" people.

It made sense to me. It's not just a blood pressure medication but also, a regulator of the fight-or-flight response in the brain or something like that.
One of this days I'll try to get it in some pharmacy without a prescription (I'll make up some lame excuse involving my mother and her non-existing hypertension) and I will try it out.

Did any of you guys have tried this drug before?


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## Timer (Feb 10, 2011)

I am also looking into meds which may help now with DR now.

Good work on finding this, be sure to let us know if any joy with it, sounds promising.


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## Brando2600 (Apr 22, 2010)

Quarter Pounder said:


> One of this days


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## Quarter Pounder (Jun 17, 2011)

Brando2600 said:


> So do tricyclic anti-depressants, just to let you know.


Lol, wish you were here to explain me what's your fucking point


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## Brando2600 (Apr 22, 2010)

Quarter Pounder said:


> Lol, wish you were here to explain me what's your fucking point


Keep your pants on, I was just making a statement.


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## flat (Jun 18, 2006)

When I tried a blood pressure drug called Diovan (actually it WAS my mother's lol) it greatly reduced my dp/dr. Not sure why cuz it only affects a hormone called angiostensin II found in blood vessels. Nothing to do with any fight-or-flight hormones.


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## Quarter Pounder (Jun 17, 2011)

Timer said:


> When I tried a blood pressure drug called Diovan (actually it WAS my mother's lol) it greatly reduced my dp/dr. Not sure why cuz it only affects a hormone called angiostensin II found in blood vessels. Nothing to do with any fight-or-flight hormones.


That's odd... Maybe blood pressure drugs have something to do with DP/DR, or perhaps it's just a coincidence. Anyways, if _prazosin_ (the drug I was talking about) doesn't do the job and if I can somehow make up an excuse to buy Diovan without a prescription, I'll try it out!


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## flat (Jun 18, 2006)

It could be possible that parts of our brain isn't getting enuff blood or oxygen (like a partial stroke) and blood pressure meds that widen blood vessels and increase blood flow might be helpful.


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## Totally DP'D (Jun 8, 2011)

Just came across this thread...

I've often been measured with high blood pressure-but this has always been due to anxiety- so called 'white coat hypertension'. Whenever I've measured my blood pressure myself it's been normal, and was at the doc's when I last went.

So since there is a link between anxiety and blood pressure, and anxiety and DP, maybe there is a link there. Certainly, beta-blockers (e.g. Propanolol) are prescribed for anxiety, because they can reduce palpitations etc.


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## Quarter Pounder (Jun 17, 2011)

Totally DP said:


> So since there is a link between anxiety and blood pressure, and anxiety and DP, maybe there is a link there. Certainly, beta-blockers (e.g. Propanolol) are prescribed for anxiety, because they can reduce palpitations etc.


Yeah, it could be. Although, I have no anxiety... AT ALL, even less than normal people, so that wouldn't work for me I guess. I pretty much don't feel anything, so my palpitations are always in a normal range.
But for people with anxiety and depersonalization, that so-called link -if you are correct and does exist- would be really significant.


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## crthomps (Jun 23, 2013)

not dredge up an old thread, but ive been on prazosin for DPD for 2 months now. No noticeable effect.


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## Victor Ouriques (Jul 15, 2011)

crthomps said:


> not dredge up an old thread, but ive been on prazosin for DPD for 2 months now. No noticeable effect.


DP or DR? Both?


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